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This is an important trial and I think the term landmark is appropriate. Nissen emphasized, though, that these are just topline results shared by news release

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Considering that GLP-1 infusion increases postprandial satiety in normal weight 7 as well as obese humans, 14 a delay in the postprandial GLP-1 response might affect food intake regulation and in particular impact inter-meal snacking that has been shown to be augmented after sleep loss

When mental health is taken into account during treatment planning, some may be more likely to experience positive outcomes

Semaglutide was approved in 2017 as Ozempic for diabetes, and in 2021 as Wegovy for obesity